The neurodegenerative disorder drug developer has emerged from stealth to commercialise Howard Hughes Medical Institute research.

Faze Medicines, a US-based molecular therapeutics developer co-founded by researchers at Howard Hughes Medical Institute, has officially launched with $81m in series A funding led by venture capital firm Third Rock Ventures. Pharmaceutical firms Novartis, Eli Lilly and AbbVie also provided capital, as did Alexandria Venture Investments, the VC arm of real estate investment trust Alexandria Real Estate Equities, Catalio Capital Management and Casdin Capital. Novartis and AbbVie participated in the round through corporate venturing vehicles Novartis Venture Fund and AbbVie Ventures respectively. Laura Brass, managing director at Novartis Venture Fund, has taken a seat on Faze’s board of directors. Faze is developing treatments for neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) based on biomolecular condensates, a type of molecule that organises to perform certain cell functions, the disruption of which could play a key role in a range of diseases. The comapny’s scientific co-founders hail from Howard Hughes Medical Institute – Roy Parker, also the Cech-Leinwand endowed chair of biochemistry at University of Colorado Boulder; Mike Rosen, also the chairman of the department of biophysics at University of Texas Southwestern Medical Center; J. Paul Taylor, also a faculty chair of the cell and molecular biology department at St Jude Children’s Research Hospital; and Ron Vale, also the executive director of the Howard Hughes Medical Institute Janelia Research Campus. Third Rock Ventures partner Cary Pfeffer is interim CEO of the company. He said: “The biology of condensates is the kind of science that will rewrite textbooks – and, we believe, rewrite medicine. “Faze is founded by leading experts who have been integral to this field since its very beginnings. Their insights, coupled with the deep expertise of the team we have assembled, will enable us to realise the enormous potential of this new biology.” – A version of this article first appeared on our sister site, Global Corporate Venturing.

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